Is Insulin Made From Horse Urine?

The world of medicine is rife with myths, misconceptions, and intriguing histories.

One such misconception that has piqued curiosity over the years is the belief that insulin, a life-saving drug for diabetics, is derived from horse urine. But where did this notion originate, and how much truth does it hold?

In this article, we will journey through the history and production of insulin, addressing the question of whether it has any connection to horse urine.

Let’s unravel the facts and demystify this essential medication.

is insulin made from horse urine


Insulin is a crucial hormone produced by the pancreas that plays a vital role in regulating blood sugar (glucose) levels. Here’s a brief overview:


  • Insulin allows cells in the muscles, liver, and fat to take up glucose from the blood and store it as glycogen in the liver and muscles.
  • It helps the body use glucose for energy and store any excess in the liver for future use.
  • Insulin also prevents the liver from releasing glucose when the levels in the blood are high (post-meal) and promotes the release of glucose when levels are low (like during fasting).


  • Type 1 Diabetes: The body’s immune system destroys the cells in the pancreas that produce insulin. People with type 1 diabetes need to take insulin injections or use an insulin pump to replace the missing hormone.
  • Type 2 Diabetes: The body either doesn’t produce enough insulin or becomes resistant to its effects. Some people with type 2 diabetes may need to take insulin, especially if other treatments aren’t effective.

Insulin Therapy:

  • Before the 1980s, insulin used for treatment was primarily derived from the pancreases of pigs and cows.
  • Today, most insulin used therapeutically is human insulin or insulin analogs produced using recombinant DNA technology. This involves inserting the human gene for insulin into bacteria or yeast, which then produce insulin for medical use.

Types of Insulin:
There are various types of insulin categorized based on their onset, peak time, and duration of action:

  1. Rapid-acting: Begins to work shortly after injection and lasts for a few hours.
  2. Short-acting or Regular: Takes about 30 minutes to start working and lasts 6 to 8 hours.
  3. Intermediate-acting: Takes 1 to 2 hours to start working and lasts up to 18 hours.
  4. Long-acting: Takes a few hours to start working but lasts over 24 hours.


  • Insulin can’t be taken orally because the stomach would break it down. It’s typically injected subcutaneously (under the skin) using syringes, insulin pens, or insulin pumps.
  • Inhalable insulin is also available, though it’s not as commonly used.

Storage and Handling:

  • Insulin can lose its effectiveness if exposed to extreme temperatures. It’s typically stored in the refrigerator but can be kept at room temperature once opened for a specified period.

Insulin is a life-saving hormone for many people with diabetes. With advancements in biotechnology, the production and types of insulin have evolved, offering more options and flexibility for diabetes management.

Always consult with a healthcare provider for personalized advice and treatment related to insulin and diabetes.

Also Read : Is Kliovance Made From Horse Urine?

horse urine

Horse urine, like the urine of many animals, has been the subject of various uses, myths, and misconceptions throughout history.

Here are some points of interest related to horse urine:

Premarin: One of the most well-known associations between horse urine and medicine is the drug Premarin. The name “Premarin” stands for “PREgnant MARe’s uRINe,” from which the drug was originally derived. Premarin is a type of hormone replacement therapy (HRT) used to treat symptoms of menopause. It contains conjugated equine estrogens, which are obtained from the urine of pregnant mares.

Horse Farms for Drug Production: Due to the demand for Premarin, there have been farms specifically dedicated to keeping mares pregnant to collect their urine. This practice has been controversial due to concerns about the welfare of the horses.

Traditional Uses: Historically, urine from various animals, including horses, has been used in traditional remedies and practices in different cultures. For example, it might have been used for tanning hides or as a cleaning agent.

Analysis for Health: Just as with humans, the analysis of horse urine can provide valuable information about the health of the horse. Veterinarians might test a horse’s urine for signs of disease, dehydration, or other health issues.

Doping Tests: In horse racing and other equestrian sports, urine samples might be taken from horses to test for prohibited substances.

Myths and Misconceptions: Over the years, there have been various myths associated with horse urine, such as its use in making certain medications other than Premarin or its supposed benefits when consumed. It’s essential to differentiate between fact and fiction and rely on scientific evidence.

In summary, while horse urine has had specific applications, particularly in the production of certain medications, it’s essential to approach any claims about its uses with a critical mind and seek evidence-based information.

Also Read : Is Estradiol Made From Horse Urine?

is insulin made from horse urine?

Historically, insulin was extracted from the pancreas of pigs and cows. However, since the 1980s, the primary source of insulin for therapeutic use has been produced using recombinant DNA technology.

This method involves inserting the human gene for insulin into bacteria (usually E. coli) or yeast, which then produce insulin structurally identical to human insulin.

The misconception about insulin being derived from horse urine might arise from confusion with other medications, like Premarin, derived from pregnant mares’ urine.

However, insulin and Premarin are entirely different medications with different sources and uses.

Final Verdicts on is insulin made from horse urine

The world of medicine is vast and filled with complexities, leading to occasional misconceptions. One such misconception is the belief that insulin is derived from horse urine.

However, after delving into the history and production methods of insulin, it’s clear that this vital hormone has never been produced from horse urine.

Instead, its origins trace back to animal pancreases and, more recently, to advanced biotechnological methods using recombinant DNA technology.

It’s essential to dispel such myths to ensure that patients and the general public have accurate information about the medications they rely on.

In the case of insulin, rest assured that horse urine has no role in its production.